Wilms' Tumor 1 (WT1) Protein, Clone 6F-H2, FLEX RTU

Wilms' Tumor 1 (WT1) Protein, Clone 6F-H2, FLEX RTU. Specifications:- Antibody Solution: Autostainer Link 48. Clone: 6F-H2. Code No: IR055. EAN/UPC Code: 05700571101681. Form/Configuration: Ready-to-Use, FLEX. Full Product Name: FLEX Monoclonal Mouse Anti-Human WT1 Protein, Clone 6F-H2, Ready-to-Use (Link). Immunogen: Truncated human WT1 protein corresponding to N-terminal amino acids 1-181 (1,2). See package insert for reference(s). Isotype: IgG1, kappa. JAN Code: 4987582029499. Number of Tests: 60. Pathology Application: Formalin;HIER. Reagent Provided: Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN 3 . Species: Mouse Anti-Human. Specificity (Detailed): Alternate splicing of the WT1 transcript gene results in four distinct mRNA species which are present in different amounts. The predicted molecular weight of the WT1 protein ranges from 46 to 49 kDa depending on the mRNA species however, the WT1 proteins derived from cells migrate at 50 to 55 kDa in SDS-PAGE (4). This antibody recognizes an epitope found in the amino terminal 84 encoded amino acids of WT1. It reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2, frequently found in subsets of sporadic Wilms' tumors. In immunoprecipitation assays, the antibody has been shown to recognize full-length and in vitro translated WT1. It also detects full-length denatured WT1 (55 kDa) in Western blots of WT1 baculovirus-infected cell lysates (1). See package insert for reference(s). Volume: 12 mL.