Human Papillomavirus (HPV), Clone K1H8, Concentrate

Human Papillomavirus (HPV), Clone K1H8, Concentrate. Specifications:- Antibody Solution: Concentrate. Clone: K1H8. Code No: M3528. EAN/UPC Code: 05700571102169. Form/Configuration: Culture supernatant. Full Product Name: Monoclonal Mouse Anti-Human Papillomavirus (HPV), Clone K1H8. Immunogen: Alkaline disrupted HPV type 1 (2). See package insert for reference(s). Isotype: IgG1, kappa. JAN Code: 05700571102169. Pathology Application: Frozen;Formalin;HIER. Reagent Provided: Monoclonal mouse antibody provided in liquid form as tissue culture supernatant in 0.05 mol/L Tris-HCl, pH 7.2 and 0.015 mol/L sodium azide. This product contains stabilizing protein. Species: Mouse Anti-Human. Specificity (Detailed): Anti-human papillomavirus, clone K1H8 (anti-HPV) reacts with a non-conformational internal linear epitope of a major capsid protein of HPV-1, which is broadly expressed among the different HPV subtypes. In Western blotting, anti-HPV identified a 57 kD protein, which corresponds to the molecular weight of a major polypeptide of the capsid protein VP1. Minor bands of 47, 44, 41 and 33 kD were weakly labeled and thought to be degraded capsid proteins. Anti-HPV has been demonstrated to identify HPV-1 antigen in ELISA and to detect HPV-1 and HPV-6 by indirect immunofluorescence in infected frozen tissue sections. Anti-HPV was found to be immunoreactive with paraffin sections of formalin-fixed HPV-infected tissues which were demonstrated by Southern blot hybridization to be infected with HPV type 6, 11, 16, 18, 31, 33, 42, 51, 52, 56 and 58. Positive immunostaining was largely confined to the nuclei of infected cells. Occasionally, the cytoplasm of koilocytotic cells was observed to be immunoreactive (2). See package insert for reference(s). Volume: 1 mL.