Cytomegalovirus, Clone CCH2 + DDG9, Concentrate

Cytomegalovirus, Clone CCH2 + DDG9, Concentrate. Specifications:- Antibody Solution: Concentrate. Clone: CCH2 + DDG9. Code No: M0854. EAN/UPC Code: 05700572005896. Form/Configuration: Culture supernatant. Full Product Name: Monoclonal Mouse Anti-Cytomegalovirus, Clones CCH2 + DDG9. Immunogen: Crude cell lysates from cytomegalovirus strain Ad169-infected human embryonic fibroblasts (3). See package insert for reference(s). Isotype: IgG2a, kappa and IgG1, kappa. JAN Code: 4987582007701. Pathology Application: Frozen;Formalin;Enzyme. Reagent Provided: A mixture of two monoclonal mouse antibodies provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris-HCl, pH 7.2, and containing 15 mmol/L NaN 3 . Species: Mouse Anti-. Specificity (Detailed): Antibody CCH2 reacts with an early nuclear protein identical with the non-structural DNA-binding protein p52 (7). More than 200 human CMV isolates have been successfully typed by this antibody which, therefore, seems to recognize an epitope which is highly conserved among HCMV strains (3, 4). Antibody DDG9 reacts with an immediate early nuclear protein of about 76 kDa (3). For both antibodies, the reactivity persists also at later stages during the HCMV infection where the localisation is less distinctly nuclear and appears to be in the cytoplasm. Laser confocal microscopy, however, shows that the reaction is limited to the nuclear membrane (3). The antibodies do not cross-react with adenovirus, herpes simplex virus, and varicella zoster virus (3). See package insert for reference(s). Volume: 1 mL.