CD246, ALK Protein, Clone ALK1, Concentrate

CD246, ALK Protein, Clone ALK1, Concentrate. Specifications:- Antibody Solution: Concentrate. Clone: ALK1. Code No: M7195. EAN/UPC Code: 05700572006824. Form/Configuration: Culture supernatant. Full Product Name: Monoclonal Mouse Anti-Human CD246, ALK Protein, Clone ALK1. Immunogen: DHFR-ALK recombinant protein comprising mouse dihydrofolate reductase (DHFR) and amino acids 1359-1460 of the full length human ALK protein, corresponding to amino acids 419-520 of the chimeric NPM-ALK protein (1). See package insert for reference(s). Isotype: IgG3, kappa. JAN Code: 4987582009057. Pathology Application: Frozen;Formalin;HIER. Reagent Provided: Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris-HCl, pH 7.2, and containing 15 mmol/L NaN 3 . Species: Mouse Anti-Human. Specificity (Detailed): The antibody was clustered as anti-CD246 at the Seventh International Workshop and Conference on Human Leucocyte Differentiation Antigens held in Harrogate in 2000 (3). In Western blotting of lysate of the t(2;5)+ SU-DHL-1 cell line, the antibody labels a band of 80 kDa corresponding to the NPM-ALK protein. The antibody also recognizes a band of 200 kDa corresponding to the ALK protein in the human rhabdomyosarcoma cell line Rh30, that expresses full length ALK protein, and in the 293T cell line transfected with cDNA encoding full length ALK protein. No reactivity was observed when the 293T cell line was transfected with the vector alone (1). See package insert for reference(s). Volume: 1 mL.